Developer Knight Dragon commissioned “starchitect” Santiago Calatrava to design the scheme above North Greenwich station.
He has created a glass galleria and 80ft high “winter garden” atrium surrounded by three towers.
The development will also be linked to the other side of the Thames by a new bridge.
The Peninsula Place scheme will include 800 apartments, 30,000 sq ft of offices, a hotel and around 80 shops, restaurants and bars.
The bus station will be rebuilt while the tube station will remain open during construction.
Mr Calatrava told the Standard: “It is an honour to be designing such a piece of the fabric of London, a city I love. In designing this scheme, I have been inspired by London’s rich architectural heritage and the very special geography of the Peninsula.
“It will be a project that reflects both this and the ambition of Knight Dragon for Greenwich Peninsula.”
Mayor of London Sadiq Khan, said: “Peninsula Place will create a new buzzing, cultural destination in the capital, which I’m confident will attract visitors not only from London, but around the globe.
“The iconic building – designed by world leading architect Santiago Calatrava – will be a truly fitting pathway onto the Peninsula, with the development offering an improved tube and bus station, alongside new shops and homes.
“This investment in key infrastructure in the capital is a vote of confidence post-Brexit and shows that London is open to business, trade and attracting the greatest talent from around the world.”