MSG want to build the 90-metre tall scheme on a 4.7 acre former coach park near the Olympic Park.
The 120-metre diameter building will take three-years to construct and will have a capacity of 21,500 people.
The sphere will sit on a four-storey base filling the whole site and its exterior will be clad with triangular LED panels displaying moving images.
Alongside the main venue MSG also plans a smaller music club/nightclub, retail space, a café, and restaurants.
Jayne McGivern, MSG’s Executive Vice President of Development and Construction, said: “This is an opportunity to take an inaccessible coach park and use it to support thousands of jobs, and billions of pounds of economic benefit.
“Our plans make training and local hiring a priority and would create a premier destination that serves as a long-term investment in the future of Newham, London, and the UK.
“If our plans are approved, we believe MSG Sphere will complement London’s existing venues and drive overall growth in the music and entertainment market – benefiting residents, artists and fans.”