Brent Council has granted outline permission for up to 1,600 new homes, as well as the student facilities, commercial space, and a replacement nursery across 19 buildings on the site.
Around 40% of the homes are for affordable tenures including Shared Ownership, London Living Rent, Intermediate Rent and London Affordable Rent.
Planning for a new access road and for phase one of development for 654 homes was granted back in December.
The overall transformation of Northwick park is being delivered through a partnership between Network Homes, London North West Healthcare NHS Trust, Brent Council and the University of Westminster.
The plans will see Northwick Park turned into a landmark destination with new high-quality homes, a modernised university hospital, improved infrastructure, and transport connections, as well as improved public spaces and enhanced facilities for education and employment.
Bhupinder Singh Chawla, partner at architects PRP, said: “The masterplan is made up of different character areas that respond to the varying edges and contexts of the site.
“A variety of typologies from apartments, maisonettes, key worker homes and mews houses add further diversity. The masterplan also provides educational, sports leisure and commercial facilities and is supported further by a strong approach to the public realm and amenity on the site which all help to create an individual identity for this new place and destination.”