The 10-acre site, which represents the last major brownfield site around the City, will ultimately be built out in a series of 9 plots.
The full plans will provide 500 homes, with 50% affordable, as well as 1.4 million sq ft of workspace, including one of the largest single contributions of affordable workspace of any development in London.
The developers have now got clearance to start work on the first cluster of buildings on plot 1 running alongside Shoreditch High Street and Bethnal Green Road where the existing Box Park temporary shopping mall exists.
Plot 1 involves construction of a large footprint 18-storey office building overflying the Shoreditch Station box and running along Bethnal Green Road.
Formed as two connected buildings, the scheme will provide 550,000 sq ft of office floorspace and ground-floor retail.
The developers have also gained reserve matters approval for the restoration of historic buildings on Sclater Street.
Designed by Gensler and Buckley Gray Yeoman, the reserved matters approval marks the next stage in the realisation of the approved scheme.
Outline construction logistics were drawn up by WSP Transport while Hoare Lea provided energy and sustainability services.